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Sorafenib, a multikinase inhibitor, is considered as the only approved drug to cure the advanced hepatocellular carcinoma (HCC); however, the acquired chemoresistance caused by intratumoral. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the. In conclusion, we demonstrated that (i) 125 I‐labeled M75 Mab selectively binds to tumor cell lines that express CA IX in a hypoxia‐dependent manner; (ii) CA IX is capable of mediating fast and efficient internalization of bound 125 I‐M75; (iii) intravenous administration of 125 I‐M75 to nude mice xenografted with HT‐29 human. 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